THEORY OF MIND, THE CORPUS COLLOSUM, AUTISIM AND ASPERGERS w/ a smidge o' KIM PEEK
KIM PEEK
Steven Wiltshire
http://www.youtube.com/watch?v=ckqDX2XpdyY&feature=related
A. What Causes Autism?
| No one really knows what causes autism, but it is suspected there may be many causes or combinations of causes. We now suspect, thanks to modern techniques of brain-scanning, that the difference in an autistic's brain lies in the structure at the centre of the brain called the amygdala. One important job of the amygdala is to interpret facial expressions and non-verbal communication. Recent research has shown that whilst the amgydala appears normal in most brain scans (such as MRIs), there are specialist 3-D scans which reveal it is flatter in ACs. Also, in the frontal lobes there is an area known as the "social brain" which is involved in the understanding and interpretation of "social rules" and understanding Theory of Mind (see Issues: Theory of Mind). The social brain contains specialised cells called Purkinje neurons. These cells are apparently scarcer in AC brains than NT brains. Many people believe that autistics are generally born autistic, they do not become that way. In fact, DSM-IV states that symptoms must have been present before 3 years old, for a diagnosis. Others believe that autism can be acquired later on. In the bad old days, autism was thought to be caused by cold and distant mothers who had inadequately bonded with their babies, the so-called "Refridgerator Mother Syndrome". Although the term was first coined by Kanner (who later recanted of the theory), it will be forever associated with it's main proponent, Bruno Bettelheim (from book "The Empty Fortress". For another view, see his biography "The Creation of Dr.B" by Richard Pollak). Believing in this theory, Bettelheim promoted a treatment centred around giving psychotherapy to parents, in an attempt to help them "bond" with these children. It didn't work, but unfortunately, the Refridgerator Mother theory refuses to die. Hardly a year goes by when we don't see it rear it's ugly head again. Even today, there are centres in the world who "treat" autism by counselling the parents; and there are still psychiatrists and psychologists who would happily blame the parents for their child's disability. In reality, there is a considerable amount of evidence that genetic factors may play a part, since ASDs often seem to run in families. Other factors that have been blamed include:
It is likely that some children may be affected by some of these factors, or combinations of factors, but as yet, researchers have been unable to pinpoint a single cause, or group of causes that would explain all or most ASDs. However, there are some researchers who are very evangelical about their particular theories. Time will tell if they are on the right track. Research is continuing, but in the meantime, it is important that parents avoid the temptation to blame themselves and obsess about everything they may have ever done that wasn't optimal. |
| |
B. The Infamous Cure Debate
There is currently no cure for ASDs, so why the debate? And why "infamous"? Intermittently on a.s.a., someone brings up the subject: "What if there was a cure for ASDs?
Not a treatment for unpleasant symptoms, not relief from discomforts, but a permanant, irreversible cure for whatever it is in the brain of a person, that causes them to be autistic.
The first aspect to the debate is the meaning of the word "cure", which some would see as relief from discomfort and psychological pain; and others would see as completely transforming the AC to be NT. Generally, the people who are opposed to a "cure" are those who would see it in absolute terms, as the total removal of the differences that make a person fit under the diagnostic criteria as "ASD". Those in favour often use the word interchangably with the word "treatment".
Invariably, a huge debate is generated. There are two main "sides" to this debate:
- Those who feel that their ASD is an intrinsic part of who they are. Remove the ASD, you remove their personality, and they cease to exist. This group see "cure" as a kind of death.
- Those who feel that the person is still the same person without the ASD, and that since the ASD causes suffering, it should be removed, should that ever become possible. Or, that the AC would not be quite the same person without the ASD, but changing personality, when your life is full of suffering, isn't much of a loss.
The former group believe that it is not ASDs themselves that cause suffering, but society's treatment of ACs and associated mental illnesses (such as OCD) which could be treated without changing the personality. The latter group believe that it the ASD itself that causes the suffering, and that relieving suffering is their principal goal (and of course, there are a lot of people in the middle who believe that ASDs cause suffering, but still don't want to be cured.)
In past debates, the former group have accused the latter of believing in a kind of euthanasia; and the latter have accused the former of wishing to perpetuate suffering. Since both positions were supported by ACs, with tendancies towards rigid thinking and explosive tempers, the debate quickly became ugly.As ever on a.s.a., it was all forgotten quickly, but if you dare to mention the word "cure", be warned. It could all start up again!
Theory of Mind
| Theory of Mind is a topic that comes up regularly on a.s.a., frequently leading to complex philosophical debates. Contents:1. DefinitionThe meaning of the term is very difficult, but my understanding is that it refers to the innate ability of one person to sense the state of mind of another (a kind of empathy, in a way); and to be able to see the world through another person's eyes, another person's point of view. If you have T.O.M., you will instinctively understand that just because you know something, it doesn't mean that I know it too. It is as if people who lack T.O.M. assume others are telepathic, and explains why some ACs often open with statements that seem to come from the middle of a conversation, not the beginning, not giving all the necessary background to ascertain the context. The debate generally centres around the belief that ACs invariably lack T.O.M. Does T.O.M. even exist? Is it perhaps a learned behaviour for everyone that ACs aren't so good at? Is it just psycho-babble? 2. The Sally-Ann TestThe Sally-Ann test is a famous test used to judge whether a person has T.O.M. or not, and the test itself probably explains what T.O.M is, better than I can. Children are supposed to be able to do this test by around 6-8 years old. The procedure goes thus: You introduce the child to two dolls, Sally and Ann, and show the child that each doll has her own box, with a marble hidden inside. Then you tell the child that Sally is going out for a minute, and remove the doll from the scene, leaving her box behind. Next, you tell the child that Ann is going to play a trick on Sally: she opens Sally's box, removes the marble, hiding it in her own box. Sally returns, unaware of what happened and you ask the child where Sally would look for her marble. A child with Theory of Mind will realise that Sally doesn't know that Ann has played a trick on her, and will therefore look in her own box for her marble, and discover it missing. But a child lacking in Theory of Mind will only see the situation from her own point of view, and suggest that Sally look for the marble where it actually is: in Ann's box. Very small children will not be able to guess correctly in this test, since Theory of Mind takes time to develop, but most children should be able to do the test by 6 or 7 years old at the latest and some as young as three years old can. However, it is thought that most children with ASDs will not be able to complete the test, and many AC adults cannot. But, this test should not be taken as an infallible test for ASDs. Some intelligent ACs can do the test simply by logical deduction, without truly having this mysterious ability of "Theory of Mind". Most people of low intelligence will not be able to do the test, even though they may be otherwise very sociable, such as people with Down's Syndrome. People with another disability, William's Syndrome are exceptional in their ability to do this test, despite apparently low, functional intelligence. So, whilst this test may be interesting, it doesn't necessarily tell us anything we couldn't tell by observation. But you are welcome to your own opinions - this discussion is one which will run and run! |
The Tale of Becky and the Plant Sprayer
A Story about Theory of Mind
| One of the members of our newsgroup went to a conference and heard a lady called Carol Gray speak. Carol Gray is the woman famous for developing a technique known as "Social Stories" for helping autistic people learn about social behaviour, based on the ancient idea of telling illustrative stories. But Carol Gray didn't always believe in such benign methods - for many years, she was trained in the old Behaviourism methods. It was her interactions with autistic people themselves that lead to her questioning what she had been taught and eventually lead to the development of her "Social Stories" methodology. This is how her annecdote was reported by our group member, a parent of an autistic child:
|
Neuroimaging of genesis and satiation of thirst and an interoceptor-driven theory of origins of primary consciousness
- Derek Denton*,†,‡,
- Robert Shade†,
- Frank Zamarippa§,
- Gary Egan*,
- John Blair-West†,
- Michael McKinley*,
- Jack Lancaster§, and
- Peter Fox§
+Author Affiliations
-
Contributed by Derek Denton
Abstract
There are defined hypothalamic functions in the genesis of thirst, but little is known of the cortical processes subserving consciousness of thirst notwithstanding the medical disorders that occur in psychiatric illness, addiction, and the attested decline of thirst with aging. In 10 adult males, positron emission tomography scans were made (i) during genesis of moderate thirst by infusion of i.v. hypertonic saline 0.51 M, (ii) after irrigation of the mouth with water to remove the sensation of dryness, and (iii) 3, 14, 45, and 60 minutes after drinking water to fully satiate thirst. The correlation of regional cerebral blood flow with thirst score showed the major activation to be in the posterior cingulate. Maximum thirst sensation evoked 13 highly significant activations and 9 deactivations in cingulate and parahippocampal gyri, insula, thalamus, amygdala, and mesencephalon. It is possible that cingulate sites (Brodmann’s areas 32, 24, and 31) that persisted with wet mouth but disappeared immediately after drinking to satiation may have an important role in the consciousness of thirst. Consciousness of thirst, a primal vegetative emotion, and satiation of thirst appear to be subserved by phylogenetically ancient brain regions. This is salient to current discussion on evolutionary emergence of primary consciousness.
In the face of dehydration (increase of extracellular sodium concentration) and osmotic pressure, animals actively seek water, often by using memory of the sources. This is consonant with J. Z. Young’s (1) emphasis that a general definition of intentionality is a property of mental life that refers to entities that are not observable, that is, not immediately present at the time. Longuet Higgins (2) has suggested that for an animal to have an intention, to have a goal, may require it to form an internal model—an image of the external world. Thus, thirst behavior with search for water can be interpreted as evidence of consciousness. Water deprivation with progression of thirst to the point of desire totally occupying the stream of consciousness is an exemplar of a basic vegetative system. Rullier (3) in 1821 in the Dictionaire des Sciences Medicales par une Societé de Médicins et Chirurgiens said of thirst “le sentiment le plus vif et le plus impérieux de la vie.”
The phylogeny of drinking behavior has been comprehensively analyzed by Fitzsimons (4, 5). Overall, comparative studies of drinking as physiologically apt behavior suggest thirst sensation and intentional seeking of water might have emerged very early in vertebrates, with implications in the phylogeny of consciousness. Other evidence has suggested to biologists that primal awareness emerged in animals lower in the phylogenetic scale than mammals (6–10).
The primacy of structures in the anterior wall of the third ventricle (11), the role of osmoreceptors in the circumventricular organs (12, 13), and sodium sensors within the blood–brain barrier (14) in the genesis of thirst has been reviewed in the initial report of this work (15), which concerned the correlation of changes in regional cerebral blood flow (rCBF) with change of plasma Na concentration.
Emergent knowledge of the primary hypothalamic genesis of thirst displaced the Cannon theory (16) that dry mouth was the primary cause. Sensory inflow from the dry mouth areas does, however, contribute to thirst sensation.
Disorders of thirst are important in clinical medicine. Polydipsia, which may lead to serious hyponatremia, is seen in psychiatric disorders (17, 18), as for example in schizophrenic inpatients (19, 20). Analysis of “rush” experienced by heroin and cocaine addicts showed that thirst was one of the highest of 20 ranked sensations (21) along with excitement, pleasure, and strength. Narcotics like morphine and pethidine have a large dipsogenic effect 2–6 hours after injection into rats (22). Conversely, the established decline in thirst sensation and attendant drinking behavior with aging (23–25) is conducive to hypernatremia. This is often much amplified in confused states, cerebrovascular disease, and Alzheimer’s disease (26).
A major issue in the field of genetically programmed ingestive behavior is the fact that an animal or human, when dehydrated, will drink rapidly to satiation over 3–10 minutes. Thereupon, thirst and the motivation to drink disappears (27), long before the fluid drunk could be absorbed from the gut and correct any chemical changes—systemic or in brain fluids—that might be generative of thirst. This was confirmed experimentally (15). Striking alterations in consciousness of thirst occurred independent of any change of plasma Na concentration ([Na]) or osmolality. This process of rapid satiation, albeit with variation between species in relation to whether immediate correction of the total deficit occurs, carries high survival value because it allows animals to gratify desire and exit from situations, e.g., waterholes, where they are particularly vulnerable to predators (27). Thus, the study with the behavioral sequence contrived and the changes in consciousness of thirst so entrained addressed issues of broad biological importance.
In the positron emission tomography (PET) experiments described here, thirst was contrived in 10 male volunteers by an attested method of rapid intravenous infusion of hypertonic 0.51 M NaCl, which increased plasma [Na] by 4 mmol/liter. After control scans, scans were made during increasing plasma [Na] and when thirst reached an apogee (mean of 43 min after the end of the i.v. infusion). Thereupon, the subjects rinsed their mouth with water without swallowing, which removed the “dry mouth” component, although the thirst sensation remained. After scanning this condition, in which the mouth was wet but thirst persisted, they were permitted to drink water to fully satiate thirst, and were scanned sequentially at 3, 14, 45, and 60 minutes after the act of satiation.
METHODS
Subject Preparation.
The subjects were male, aged 24–36 years, and preparation, image analysis, and institutional consent procedures for this experiment have been reported in an earlier report (15). The experimental sequence involved two control rest scans, scanned during and at the end of rapid infusion of 0.51 M NaCl, when maximum thirst developed a mean of 43 min later, after irrigation of the mouth with water, and at 3, 14, 45, and 60 min after drinking water to satiation. The principal contrasts reported are of maximum thirst, wetting the mouth, and 3 and 14 min after drinking to satiation where each condition is compared to the first preinfusion nonthirsty baseline condition. PET and MRI scans were acquired with each subject supine and with his head supported in a foam-padded, hemicylindrical head holder, with eyes closed and in a quiet room. Each of these four primary comparisons achieved significance (P <>Z statistic analyses. Two statistical thresholds were used: one for large clusters, another for smaller clusters. Large clusters (≥60 contiguous voxels) were required to have a less rigorous Z threshold (Z > 1.96; uncorrected P <>Z threshold (Z > 3.27; uncorrected P <>
A correlational analysis also was undertaken (15), whereby rCBF was correlated against the thirst scores reported by each subject for each scan. Significant activations were chosen as those with Z scores >3.27.
A second independent analysis of the data also was undertaken. An automated image registration algorithm (AIR 3.0) (28, 29) was used to align the 10 PET images of each subject, using a linear transformation, to a standard average rCBF PET image located in Talairach space. Each PET image was then resampled at a 2.0 × 2.0 × 4.0 mm voxel size. Each subject’s MRI was aligned to a standard MRI located in Talairach space, and an average of the 10 individual MRIs was computed. The PET images were smoothed by using a three-dimensional 12-mm Full-Width Half-Maximum Gaussian blurring function (AIR 3.0). Statistical parametric mapping (SPM96) (30) was used to identify voxels that had statistically significant relative rCBF changes. Subtraction analyses comparing maximum thirst, wet mouth, and 3 and 14 minutes after drinking water to satiation to the first preinfusion scan were made. Also, a subtraction analysis was made between the three conditions involving a high state of thirst (100% infusion, maximum thirst, and wet mouth) and the six conditions where little or no thirst was experienced by the subjects—namely, the initial two resting scans and the scans taken 3, 14, 45, and 60 min after drinking to satiation. Significant activations were chosen as those having Z scores >2.33 and >20 voxels.
RESULTS
As reported (15), plasma [Na] increased by 4 mmol/liter at the end of the 0.51 M NaCl infusion (0.2 ml⋅kg−1⋅min−1 for 25 or 50 min), and the increased concentration persisted over the remainder of the experiment. The subjects evaluated thirst score on the basis of 10 being equivalent to the worst thirst the subject had experienced, and 0 being no sensation of thirst. The thirst score increased during the i.v. infusion, reached apogee of 5.25 ± 0.90 (mean ± SEM) with a mean of 43 ± 2.5 min after the infusion finished. Thirst score decreased (3.55 ± 0.64) but still remained highly significantly elevated after irrigating the mouth with water, and then fell to near baseline (0.85 ± 0.43) within 3 min of drinking water to satiation. It remained near baseline for the remainder of the experiment (15).
Correlation of Thirst Score and rCBF.
The principal brain area that correlated with thirst score is shown in Fig. 1 (0, −44, 8; cluster size 113, Z = 3.76). This posterior cingulate activation area involving Brodmann’s area (BA) 29 and BA 26 was bilateral, extending from x = +6 and −6. A number of subsignificant activations were observed in the left mediodorsal nucleus of the thalamus (Z = 3.07) and the left pulvinar (x = −18, y = −24, z = −2; cluster size 42; Z = 3.16), and in the anterior cingulate in BA 24 and BA 32 (Fig. 1).
The correlation of rCBF and the change-of-thirst score derived from 99 PET scans from 10 subjects during the experimental sequence. The sections are at x = −8, x = −2, and x = + 2 and show activations (red-yellow) and deactivations (blue-green). The color coding of Z scores is shown in the figure. The bilateral posterior cingulate activations are evident.
Subtraction Analysis of Maximum Thirst.
The salient change in the brain associated with the development of moderate-to-severe thirst (maximum thirst minus baseline) occurred predominantly in the cingulate gyrus (10 areas with Z score > 3.08, Figs. 2 and 3). There also were highly significant activations in parahippocampal, insula, and thalamic areas (Table 1 and Fig. 2). The cingulate areas involved anterior (Table 1) and two less strong activations in the posterior cingulate region, i.e., BA 29 (x = −4, y = −42, z = 20; cluster size 33, Z = 3.17; and x = −2, y = −44, z = 8; cluster size 51; Z = 3.11). There were also six foci in the midcingulate (y = −4 to y = −16). Overall, BA 24, 9, 32, and 29 were involved. Cingulate, amygdala, parahippocampus, thalamic, and two brainstem areas, one in the region of the paranigral pigmented and parabrachial nucleus (31) were contemporaneously highly significantly deactivated (Figs. 2 and 3). Maximum thirst was associated with parietal activation; the strongest focus was in the mouth region of the post-central gyrus and disappeared with wetting the mouth (Table 1, Fig. 2).
The volume (mm3) of the regional activations and deactivations observed in each brain region during maximum thirst, 5 min after wetting the mouth, 3 min after drinking to satiation, and 14 min after drinking to satiation are shown as a stacked bar graph. “Rest of limbic” refers collectively to the parahippocampal and insula cortex and amygdala and also includes the thalamus. The activation volumes were determined by adding all voxels with Z score >3.08 and deactivation by adding voxels with Z score <−3.08. MT, maximum thirst; WM, wet mouth; D + 3, 3 min after drinking water to satiation; D + 14, 14 minutes after drinking water to satiation.
Changes in rCBF relative to resting PET scans
(Left) The PET activations (saggital section x = −2) of the average brain of the 10 subjects where initial resting non-thirsty state is compared with maximum thirst (Top), 5 min after wetting the mouth (Middle), and 3 min after drinking to satiation (Bottom). Only significant activations (Z > 1.96) and deactivations (Z < −1.96) are shown as per color bars. (The color coding of Z scores is shown on the figure.) (Right) Logical images formed by logical AND (cyan: present in both) of two activation statistical images, and logical NOT (red: present in first but not second) of the two activation images as indicated by arrows. Each logical image is formed from two statistical images as indicated by the arrows on the right of the statistical images.
Wetting the Mouth During Maximum Thirst.
Irrigating the mouth with water caused reduction of cingulate activation, although highly significant foci persisted in the anterior, mid-, and posterior cingulate (Table 1) (BA 24, 32, and 31), which disappeared immediately after drinking to satiation (Fig. 3; Table 1). Wetting the mouth caused a number of strong frontal activations to appear, particularly in BA 47 (Table 1). Also, deactivation foci appeared (Table 1), particularly in the posterior cingulate and parahippocampal regions (BA 31, 30, 19, 36).
Satiation of Thirst.
By 3 min after drinking water to satiation, the major activations in the cingulate had disappeared (Table 1, Fig. 3). However, by 14 min, a new highly significant activation had appeared in the mid-cingulate in BA 24 (x = −14, y = 4, z = 38; Z = 4.17) (Table 1).
Whereas with the criterion of significance employed no activation sites were detected in mesencephalon and diencephalon with maximum thirst, two highly significant activation foci had emerged 14 min after drinking to satiation, one in the midbrain in the periaqueductal gray (x = −6, y = −28, z = −4) and one in the pons (Table 1).
In addition to the primary contrasts described in the preceding paragraphs, secondary contrasts were created by applying logical operators (AND, OR, NOT) to pairs of the statistical images. The purpose of this analysis was to highlight activations unique to one state or common between two or more states. Fig. 3 reflects such a saggital section at x = −2. Anterior cingulate cortex activity persisted after wetting of the mouth, an overlap (cyan) occurred in BA 32, and the anterior cingulate activity returned to baseline levels after drinking to satiation (Fig. 3). Overall, maximum thirst was uniquely associated with diffuse activation of the limbic and paralimbic cortex (Table 1).
As an independent appraisal, these data were also analyzed by using SPM (Methods). The major brain activations with maximum thirst relative to baseline were bilateral in the anterior cingulate at BA 32 (Z = 3.21; Z = 2.77) at Talairach coordinates (x = −6, y = 34, z = 24) and (x = 12, y = 34, z = 4), respectively and at postcingulate (x = 14, y = −44, z = 8; Z = 2.75) (BA 29). An activation also was observed in the left lobus paracentralis at BA 31 (x = −10, y = −26, z = 44; Z = 2.18). After wetting the mouth, brain activations were again observed bilaterally in the anterior cingulate (Z = 2.79; Z = 3.13) at Talairach coordinates (x = −12, y = 34, z = 4 and x = 6, y = 14, z = 36), respectively. Activations also were observed in the medial right frontal cortex, BA 11 (x = 21, y = 40, z = 12; Z = 3.21). Three minutes after drinking to satiation, the medial anterior cingulate regions were no longer activated; instead, the major activations were observed in the right precentral gyrus at BA 6 (x = 42, y = 2, z = 28; Z = 3.59) in the right lateral posterior thalamus (x = 18, y = −22, z = 16; Z = 3.39;), and in the right superior temporal gyrus at BA 22 (x = 64, y = −34, z = 8; Z = 2.8). Fourteen minutes after drinking to satiation, a new strong activation in the left cingulate gyrus (x = −14, y = −4, z = 32; Z = 3.48) was observed.
A categorical subtraction analysis (100% infusion, + maximum thirst + wet mouth) compared to (rest 1, + rest 2, + satiation at +3 min, +14 min, +45 min, + 60 min) showed major effects in BA 32 and BA 24 (namely, x = 10, y = 24, z = 32; cluster size 114, Z = 3.15, and x = 0, y = 20, z = 32; Z = 2.61) for BA 32, and (x = 12, y = −10, z = 44; cluster size 35, Z = 2.74) for BA 24. Bilateral strong claustrum activation also occurred (x = 32, y = −20, z = 8; cluster size 57; Z = 3.26); and (x = −32, y = −14, z = 12; cluster size 37; Z = 2.82).
The changes in rCBF at the four strongest activations from this subtraction analysis show a progressive rise in rCBF during the infusion scans, with maximum value occurring with wet mouth, and an obvious decrease of rCBF occurred by 3 min after drinking to satiation. The final rCBF (scans 9 and 10) was equivalent to the initial (scans 1 and 2) (Fig. 4).
The mean rCBF for the 10 subjects at the location of the four strongest activations identified in the subtraction analysis involving the high state of thirst (100% infusion, maximum thirst, and wet mouth) compared with the six scans in which thirst was absent or minimal. The maximal rCBF was reached with the wet mouth scan, and a clear decrease of rCBF occurred 3 min after drinking water to satiation, and by 45 and 60 min, it had returned to the initial rCBF level.
The analysis with the two independent methods highlighted predominance of the cingulate as the site of the most robust activations.
DISCUSSION
General Biological Aspects.
Three results with biomedical importance emerge from this study. First, the genesis of a compelling consciousness of thirst involving a contemporaneous awareness of dryness of the mouth caused striking activation and inhibitory processes in phylogenetically ancient brain regions. The areas involved—parahippocampus, amygdala, and thalamus—are present in reptiles and amphibians (32). Together with cingulate areas and insula, the cortical elements include allocortex and transitional cortex that differ structurally from the isocortex characteristic of the association areas, which contain six more or less pronounced layers (33–35). The five-layered cortex of the cingulate regions appears in the earliest mammals (36), but there are differing views (35, 37, 38) regarding the phylogeny of these limbic areas. Butler and Hodos (38) state that the current evidence indicates that the limbic system evolved long before the advent of any amniote vertebrates, let alone early mammals. Overall, the findings are consonant with the concept of thirst as a primitive vegetative function with much of its circuitry emergent early in vertebrate evolution.
Second, Bernard’s (39) experiments on copious drinking with an open esophageal fistula relegated “dry mouth” to a secondary role in thirst genesis. The data here showed reduction of activation foci with wetting of the mouth, not only in parietal sensory areas, but in the limbic system and particularly the cingulate foci. However, the data showed persistence of some cingulate foci after mouth wetting. The results support Cannon’s view (16) of the importance of dry mouth in thirst, but, like the open fistula experiment and the avid drinking in dehydrated ruminants that have continuous salivary secretion (27), they vitiate any notion of a dominant causal role.
Third, the consummatory act of rapid drinking was associated with contemporaneous loss of thirst and the major of the anterior and posterior cingulate activations within 3 min of completion. Characteristically, gratification occurred without any alteration in plasma [Na] or osmolality (27, 40). A new activation appeared caudally in the midcingulum 14 min after drinking to satiation (BA 24). A strong active focus appeared in the midbrain close to the aqueduct, which is of interest in the light of attested cingulate pathways to periaqueductal gray. Satiation also caused several strong limbic deactivations—mainly posterior cingulate, insula, and thalamic. Further experiments will be required to evaluate significance of these regions in the consciousness of gratification. The trio of sensory inflow from mouth, esophageal monitoring of volume swallowed, and gastric distension appears to be jointly sufficient and severally necessary to abolish thirst (27).
Paramount Role of the Limbic System.
The outstanding cerebral effect of significant thirst and dry mouth was a general functional change in the limbic system and entities involved in the Papez circuit (41). The term “limbic system” is used here as a loose construct to imply that limbic cortex and its primary brainstem connections constitute a system involving functional integration (35). Later studies have doubted the value of the concept of a limbic system and stressed the complexity of cortical connections of the hypothalamus (42, 43).
Significant thirst may be termed a primal compelling emotion. In terms of difference from some other emotional states, thirst, when severe, is relatively inaccessible to cognitive amelioration, in contrast to the situation to a variable degree with, for example, anger, hatred, love, sexual desire, territoriality, and fear. Underlying this putative dichotomy may be the fact that the latter emotions involve situational perceptions based on distance receptor input. Thirst, however, is interoceptor-driven and initiated through mechanisms in the phylogenetically ancient basal brain, as with hunger for air. The relative inaccessability of the primal emotion to higher cognitive amelioration may reside in this fundamental of brain organization.
The anterior cingulate receives extensive inputs from the remainder of the limbic system and other regions of the cerebral cortex, especially from areas frequently designated as associative (33, 34, 46, 47). In monkeys, BA 32 receives afferents from BA 9, the temporal pole, and the orbitofrontal cortex (47). The anterior cingulate was the site of activations correlating with change of plasma [Na] in these experiments (15) and some of the wide ranging connections of this region as described by Vogt and others (46, 47) were noted there. There is evidence that the anterior and posterior cingulate are functionally and anatomically coupled through an intracingulate neural network (46, 47). Whether the predominant correlation of the anterior cingulate foci with changes in plasma [Na] (15), and whether the posterior cingulate region with thirst reflects such a functional interconnection subserving genesis of thirst, awaits further investigation.
The posterior cingulate cortex is involved in processes underlying spatial memory and visual association areas, and somatosensory association areas send afferents to the posterior as well as anterior part of the cingulate cortex (34, 48). Afferents also come from the hippocampus (34, 46) and anterior thalamic nuclei. The subtraction studies in which the six low thirst score images were subtracted from conditions of highest thirst score (i.e., end of infusion, maximum thirst, and wet mouth) also showed major activations in the anterior and middle cingulate—BA 32 and BA 24. The bilateral activations also seen in the claustrum were interesting because, inter alia, it receives afferents from the hypothalamus and intralaminar nucleus of the dorsal thalamus (38). Some caution is noted in attributing this bilateral activation to the claustrum in light of its close proximity to the deep insula, which has involvement in salivation and mouth movement.
In relation to major effects in other lobes, the frontal activations (BA 47, 45, and 11) that appeared with wetting the mouth and disappeared with drinking to satiation were striking, and of particular interest in the light of the data of Rolls in monkeys showing there are neurons in the orbitofrontal cortex that respond to taste of water (49). Furthermore, the activity of these neurons was greatest when the monkeys were thirsty, whereas, following satiation, their firing reduced to baseline (49). In our experiments, the large frontal response to the wetting of the mouth while thirst persisted and the disappearance of this effect when the mouth was wet (but wet as a result of drinking water to satiation) was consistent with Rolls’ data. Clinical data does not suggest removal or damage of frontal lobes deranges thirst (33). Vascular lesions damaging the anterior cingulate cause mutism with or without akinesia (51), which are clinical conditions in which thirst derangement may not be evident without systematic study of blood chemistry.
Thalamic activations and deactivations were prominent in the experiment, and connections of the thalamus to the anterior and posterior cingulate, brain stem, hypothalamus, and amygdala are well established (50). The thalamus is a relay of sensory afferent inflow as would have occurred with the dry mouth. The left parahippocampus (BA 28), very strongly activated in maximum thirst, projects to the cingulate, and there is cingulate–parahippocampal continuity rounding the splenium of the corpus callosum.
Evolutionary Considerations.
In relation to current general discussion of the phylogenetic emergence of consciousness, Edelman (7) has proposed that it is the evolutionary development of the ability to create a scene that led to the emergence of primary consciousness. He says, “The word ‘scene’ is meant to convey the idea that responses to roughly contemporaneous events in the world are connected by a set of re-entrant processes… we experience primary consciousness as a ‘picture’ or ‘mental image’ of ongoing categorized events.” Alternate to this primarily distance receptor concept, a theory that has been advanced is that primary awareness might have emerged with the basic vegetative systems, and, accordingly, from interoceptor-initiated brain events (11). That is, the evolutionary origin might have come from sensations and primal emotions arising from sensors and receptors, both internal and surface, signaling that the existence of the creature was immediately threatened—for example, hunger for air, thirst, hunger, pain, and extreme temperature change (13). The basic vegetative systems have control centered in the phylogenetically ancient areas of the brain (mesencephalon and diencephalon), which is also the case with the elemental processes of arousal and of sleep. It is salient, however, to Edelman’s view that the optic tectum is a major anatomical feature in, e.g., the lamprey, alligator, shark, and pigeon. The optic tectum is the recipient of inflow from optic nerves, and in many fishes it is larger than the cerebral hemispheres (32).
The results in this study underscore that thirst is subserved by a complex distributed pattern of activation and deactivation, the functional changes being mainly in phylogenetically ancient brain areas. The data suggests that the anterior and posterior cingulate, as well as the anterior wall of the third ventricle, are major elements of a pattern including thalamic, hippocampal, orbitofrontal, insula, and midbrain sites that subserve the genesis of consciousness of thirst when plasma [Na] increases. A prototypical primal vegetative emotion like thirst is likely in humans to be evocative of memories of sources of fluid and of the pleasures of gratification, thus giving rise to a complex conscious experience, and this possibly might have contributed to some activity in association areas seen here. It is feasible the complex pattern of activations and deactivations found here represent a “dynamic core” (52) of functionally integrated, but anatomically distributed, processes subserving consciousness of thirst.
Acknowledgments
The authors appreciate discussion and bibliographic suggestion from Dr. Helen Mayberg, Dr. Fred Plum, Dr. John McKenzie, Professor Fred Mendelsohn, and Professor David Copolov. This work was supported by the Robert J. Jr. and Helen C. Kleberg Foundation, the G. Harold and Leila Y. Mathers Charitable Foundation, The Howard Florey Biomedical Foundation of the U.S., and the National Health and Medical Research Council of Australia.
Footnotes
-
↵ ‡ To whom reprint requests should be addressed. e-mail: d.denton@hfi.unimelb.edu.au.
- ABBREVIATIONS:
- BA,
- Brodmann’s area;
- rCBF,
- regional cerebral blood flow;
- PET,
- positron emission tomography
- Copyright © 1999, The National Academy of Sciences
References
Articles citing this article
posted by Infinitesimal @ 7/18/2009 09:48:00 PM
1 Comments:
At Monday, July 20, 2009 2:12:00 PM,
Spring said…
Ummm...been doing a bit of reading, have we? ;)
Post a Comment
<< Home